Local Cortical Tension by Myosin II Guides 3D Endothelial Cell Branching
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چکیده
منابع مشابه
Local Cortical Tension by Myosin II Guides 3D Endothelial Cell Branching
A key feature of angiogenesis is directional control of endothelial cell (EC) morphogenesis and movement [1]. During angiogenic sprouting, endothelial "tip cells" directionally branch from existing vessels in response to biochemical cues such as VEGF or hypoxia and migrate and invade the surrounding extracellular matrix (ECM) in a process that requires ECM remodeling by matrix metalloproteases ...
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In many cases cell function is intimately linked to cell shape control. We utilized endothelial cell branching morphogenesis as a model to understand the role of myosin-II in shape control of invasive cells migrating in 3D collagen gels. We applied principles of differential geometry and mathematical morphology to 3D image sets to parameterize cell branch structure and local cell surface curvat...
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Myosin Phosphatase and Cofilin Mediate cAMP/PKA-induced Decline in Endothelial Cell Isometric Tension and Myosin II RLC Phosphorylation Zoe Goeckeler and Robert Wysolmerski Department of Pathology, St. Louis University School of Medicine, St. Louis, Missouri 63104 Running title: cAMP and Endothelial Cell Isometric Tension Address correspondence to: Robert B. Wysolmerski, Department of Pathology...
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Axis elongation in Drosophila occurs through polarized cell rearrangements driven by actomyosin contractility. Myosin II promotes neighbor exchange through the contraction of single cell boundaries, while the contraction of myosin II structures spanning multiple pairs of cells leads to rosette formation. Here we show that multicellular actomyosin cables form at a higher frequency than expected ...
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Plasma membrane tension is an important feature that determines the cell shape and influences processes such as cell motility, spreading, endocytosis and exocytosis. Unconventional class 1 myosins are potent regulators of plasma membrane tension because they physically link the plasma membrane with adjacent cytoskeleton. We identified nuclear myosin 1 (NM1) - a putative nuclear isoform of myosi...
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ژورنال
عنوان ژورنال: Current Biology
سال: 2009
ISSN: 0960-9822
DOI: 10.1016/j.cub.2008.12.045